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交醫(yī)生命科學(xué)中心 (交一生物材料與再生醫(yī)學(xué)技術(shù)中心)

交一生物材料與再生醫(yī)學(xué)技術(shù)中心專(zhuān)注于自體細(xì)胞與生物墨水在再生醫(yī)學(xué)領(lǐng)域的研究與應(yīng)用。作為一種前沿的醫(yī)學(xué)技術(shù)，自體細(xì)胞能夠通過(guò)重新編程和分化，實(shí)現(xiàn)人體組織的再生與修復(fù)。而生物墨水則是一種含有活體細(xì)胞和生物材料的可注入液體，用于3D打印人體組織和器官。

中心的研究團(tuán)隊(duì)致力于開(kāi)發(fā)先進(jìn)的自體細(xì)胞分離、培養(yǎng)和擴(kuò)增技術(shù)，以提高自體細(xì)胞在再生醫(yī)學(xué)中的應(yīng)用效果。同時(shí)，中心還研究設(shè)計(jì)創(chuàng)新的生物墨水，以解決人工器官和組織移植中的供給問(wèn)題。

中心與多家醫(yī)療機(jī)構(gòu)、科研院所和企業(yè)展開(kāi)合作，共同推動(dòng)相關(guān)技術(shù)的發(fā)展和轉(zhuǎn)化。通過(guò)深入了解人體生物學(xué)特性和創(chuàng)新技術(shù)的應(yīng)用，中心為實(shí)現(xiàn)個(gè)性化醫(yī)療和器官再生提供了有力的支持。

中心的目標(biāo)是在自體細(xì)胞和生物墨水研究方面取得突破性的進(jìn)展，并將其應(yīng)用于各種再生醫(yī)學(xué)領(lǐng)域，包括組織工程、器官再生和藥物篩選。通過(guò)跨學(xué)科的合作和持續(xù)創(chuàng)新，中心致力于為人類(lèi)健康和醫(yī)學(xué)進(jìn)步做出貢獻(xiàn)。

劉昌勝 1967年6月出生于湖北大冶，生物材料學(xué)家，中國(guó)科學(xué)院院士，華東理工大學(xué)教授、博士生導(dǎo)師，上海大學(xué)校長(zhǎng)、黨委副書(shū)記 。 長(zhǎng)期從事生物材料的研究，發(fā)展了多種活性骨修復(fù)材料以及生長(zhǎng)因子制備和材料活化新技術(shù)；研制出自固化磷酸鈣人工骨并獲此類(lèi)產(chǎn)品注冊(cè)證，實(shí)現(xiàn)臨床廣泛應(yīng)用。 劉昌勝提出了仿生人體創(chuàng)傷自愈合過(guò)程、構(gòu)建材料在體內(nèi)引導(dǎo)組織原位再生的學(xué)術(shù)思路，利用材料在體內(nèi)所激發(fā)的系列生物學(xué)效應(yīng)， 實(shí)現(xiàn)無(wú)生命材料向有生命組織的轉(zhuǎn)化。研制出自固化磷酸鈣人工骨，實(shí)現(xiàn)了準(zhǔn)確塑形、生物降解、同步成骨特性統(tǒng)一，獲國(guó)家藥監(jiān)局該類(lèi)產(chǎn)品首張注冊(cè)證， 已廣泛應(yīng)用于臨床。發(fā)明了制備人骨生長(zhǎng)因子和材料活性化的新方法，研制出活性骨修復(fù)體已應(yīng)用于臨床，取得了滿意的治療效果 。 

學(xué)術(shù)論著 截至2017年11月，劉昌勝出版著作（教材）4部，發(fā)表SCI論文201篇，包括在生物材料領(lǐng)域權(quán)威期刊Biomaterials（生物材料）上發(fā)表21篇，以及在Chemical Reviews（化學(xué)評(píng)論）等學(xué)術(shù)雜志上發(fā)表的多篇論文。

Jinyang Li, Xue Qu, Gregory F. Payne, Cheng Zhang, Yuxin Zhang, Jianbo Li, Jie Ren, Hua Hong, Changsheng Liu, Biospecific Self-Assembly of a Nanoparticle Coating for Targeted and Stimuli-Responsive Drug Delivery, Adv. Funct. Mater. 2015. Lingyan Cao, Jing Wang, Juan Hou, Wanli Xing, Changsheng Liu, Vascularization and bone regeneration in a critical sized defect using 2-N,6-O-sulfated chitosan nanoparticles incorporating BMP-2, Biomaterials, 2014, 35(2):684-698. Lingyan Cao, Jerome A. Werkmeister, Jing Wang, Veronica Glattauer, Keith M. McLean*, Changsheng Liu*, Bone regeneration using photocrosslinked hydrogel incorporating rhBMP-2 loaded 2-N, 6-O-sulfated chitosan nanoparticles, Biomaterials, 2014,35(9): 2730-2742. Fan Yang, Jing Wang, Juan Hou, Han Guo, Changsheng Liu, Bone regeneration using cell-mediated responsive degradable PEG-based scaffolds incorporating with rhBMP-2, Biomaterials, 2013, 34: 1514-1528. Jing Zhang, Huanjun Zhou, Kai Yang, Yuan Yuan*, Changsheng Liu*, RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration, Biomaterials, 2013, 34: 9381-9392. Jun Zhao, Gang Shen, Changsheng Liu, Shaoyi Wang, Wenjie Zhang, Xiaochen Zhang, Xiuli Zhang, Dongxia Ye, Jie Wei, Zhiyuan Zhang, Xinquan Jiang, Enhanced Healing of Rat Calvarial Defects with Sulfated Chitosan-Coated Calcium-Deficient Hydroxyapatite/Bone Morphogenetic Protein 2 Scaffolds, Tissue Engineering Part A, 2012, 18(1-2): 185-197. Deliang Zeng, Lunguo Xia, Wenjie Zhang, Hui Huang, Bin Wei, Qingfeng Huang, Jie Wei, Changsheng Liu, Xinquan Jiang, Maxillary Sinus Floor Elevation Using a Tissue-Engineered Bone with Calcium-Magnesium Phosphate Cement and Bone Marrow Stromal Cells in Rabbits, Tissue Engineering Part A, 2012, 18(7-8): 870-882. Derong Zou, Lian Guo, Jiayu Lu, Xiuli Zhang, Jie Wei, Changsheng Liu, Zhiyuan Zhang, Xinquan Jiang, Engineering of Bone Using Porous Calcium Phosphate Cement and Bone Marrow Stromal Cells for Maxillary Sinus Augmentation with Simultaneous Implant Placement in Goats, Tissue Engineering Part A, 2012, 18(13-14): 1464-1478. Chenglong Dai, Han Guo, Jingxiong Lu, Jianlin Shi, Jie Wei, Changsheng Liu*, Osteogenic evaluation of calcium/magnesium-doped mesoporous silica scaffold with incorporation of rhBMP-2 by synchrotron radiation-based mCT, Biomaterials, 2011, 32: 8506-8517. Wenjie Dong , Yongsheng Li*, Dechao Niu , Zhi Ma , Jinlou Gu , Yi Chen , Wenru Zhao ,Xiaohang Liu , Changsheng Liu , and Jianlin Shi*, Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy, Adv. Mater. 2011, 23, 5392–5397. Qi Gan, Xunyu Lu, Yuan Yuan, Jiangchao Qian, Huanjun Zhou, Xun Lu, Jianlin Shi, Changsheng Liu*, A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica, Biomaterials, 2011, 32: 1932-1942. Yuan Yuan, Changsheng Liu*, Jiangchao Qian, Jing Wang, Yuan Zhang, Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells, Biomaterials, 2010, 31:730-740. Jie Wei, Junfeng Jia, FanWu, Shicheng Wei, Huanjun Zhou, Hongbo Zhang, Jung-Woog Shin, Changsheng Liu*, Hierarchically microporous/macroporous scaffold of magnesium–calcium phosphate for bone tissue regeneration, Biomaterials, 2010, 31:1260-1269. Chenglong Dai, Changsheng Liu*, Jie Wei, Hua Hong, Qinghui Zhao, Molecular imprinted macroporous chitosan coated mesoporous silica xerogels for hemorrhage control, Biomaterials, 2010, 31:7620-7630. Yan Sheng, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Fan Yang, Xiaoqian Shan, Huanjun Zhou, Feng Xu，Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan. Biomaterials, 2009, 30: 2340-2348. Jie Wei, Fangping Chen, Jung-Woog Shin, Hua Hong, Chenglong Dai, Jiancan Su, Changsheng Liu*, Preparation and characterization of bioactive mesoporous wollastonite – Polycaprolactone composite scaffold. Biomaterials, 2009,30:1080-1088. Huanjun Zhou, Jiangchao Qian, Jing Wang, Wantong Yao, Changsheng Liu*, Jianguo Chen, Xuehua Cao，Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N,6-O-sulfated chitosan in vitro and in vivo，Biomaterials，2009,30:1715-1724. Chenglong Dai, Yuan Yuan, Changsheng Liu*, Jie Wei, Hua Hong, Xiaosheng Li, Xiaohua Pan, Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control, Biomaterials, 2009, 30: 5364-5375. Min Yin, Yuan Yuan, Changsheng Liu*, Jing Wang, Development of mussel adhesive polypeptide mimics coating for in-situ inducing re-endothelialization of intravascular stent devices, Biomaterials, 2009, 30 :2764-2773. Jing Wang, Changsheng Liu*, Xin Lu, Min Yin, Copolypeptides of 3,4-Dihydroxypheny- lalanine and L-lysline to Mimic Marine Adhesive Protein, Biomaterials, 2007, 28:3456-3468. Jian Zhao, Changsheng Liu*, Yuan Yuan, Xinyi Tao, Xiaoqian Shan, Yan Sheng, Fan Wu, Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers, Biomaterials, 2007, 28:1414-1422. Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Rheological Properties of Concentrated Aqueous Injectable Calcium Phosphate Cement Slurry, Biomaterials, 2006, 27: 5003-5013. Changsheng Liu*, Huifang Shao, Feiyue Chen, Haiyan Zheng, Effects of the Granularity of Raw Materials on the Hydration and Hardening Process of Calcium Phosphate Cement, Biomaterials, 2003,24: 4103-4113. Changsheng Liu*, Wei Gai, Songhua Pan, Zisheng Liu, The Exothermal Behavior in the Hydration Process of Calcium Phosphate Cement, Biomaterials, 2003, 24:2995- 3003. Changsheng Liu*, Yue Huang, Jinhua Cui, Kinetics of Hydroxyapatite Precipitation at pH 10 to 11, Biomaterial, 2001, 22:301-306. Jing Wang, Changsheng Liu*, Yufei Liu, Shuo Zhang, Double-Network Interpenetrating Bone Cement via in situ Hybridization Protocol, Advanced Functional Materials, 2010, 20: 3997-4011.

承擔(dān)項(xiàng)目 截至2017年11月，劉昌勝作為項(xiàng)目負(fù)責(zé)人，先后承擔(dān)國(guó)家重大科學(xué)研究計(jì)劃項(xiàng)目、國(guó)家自然科學(xué)基金重點(diǎn)及面上項(xiàng)目、“863”項(xiàng)目、教育部高等學(xué)校學(xué)科創(chuàng)新引智計(jì)劃和教育部創(chuàng)新團(tuán)隊(duì)項(xiàng)目等，國(guó)家重大科學(xué)研究計(jì)劃項(xiàng)目首席科學(xué)家。 科研成果獎(jiǎng)勵(lì) 截至2017年11月，劉昌勝先后獲得國(guó)家自然科學(xué)獎(jiǎng)二等獎(jiǎng)（2014年度）、國(guó)家科技進(jìn)步二等獎(jiǎng)（2003年度）等多項(xiàng)科技獎(jiǎng)勵(lì)。獲授權(quán)發(fā)明專(zhuān)利38項(xiàng)（其中美國(guó)授權(quán)專(zhuān)利4項(xiàng)）。